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The gut and brain in adult ADHD

Digestion and the gut–brain relationship, with attention to food tolerance, daily routines and getting persistent symptoms assessed.

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When you eat, think about what supports your gut as well as what supplies a particular nutrient. This is a useful extension of looking after the whole body. Digestion is happening while we work, rest, sleep and respond to stress. Gut discomfort can occupy attention, change appetite and make a meal feel difficult. In adult ADHD care, I want those experiences brought into the conversation rather than left at the edge of it.

The gut and brain communicate through several connected processes. The gut has its own network of nerves, contains immune activity and is home to organisms that produce and respond to chemical signals. Food gives those organisms different material to work with. This is one reason to think about variety, fibre and the overall eating pattern. It gives us a wider question than “How much protein did I get?”: what does this way of eating do for digestion, nourishment and the person living through the day?

There is also a practical clinical reason to ask about gut symptoms. A large cohort study of young people serving in the Israeli military found more recorded constipation, dyspepsia and irritable bowel syndrome among those with ADHD. We should be willing to ask about bowel routines, pain, bloating and the effect these have on activity. Someone who avoids eating before leaving home may be responding to an experience they have learned to anticipate. The meaning of the routine becomes clearer when we understand that experience.

Human microbiome research in adult ADHD has found differences between groups and is examining whether those differences relate to symptoms. Intervention studies are also developing. One trial in adults with ADHD, borderline personality disorder or both, all selected for high irritability, found an irritability benefit from a particular synbiotic preparation. The attention finding was secondary. The detail of that work matters: who was treated, what was given and which outcome changed. It is useful research to follow because it asks whether altering a bodily condition can influence an aspect of psychological functioning.

For the person seeking help now, begin with the gut they actually have. What foods are tolerated? Is constipation making meals and daily activity uncomfortable? Does diarrhoea influence travel or work? Are symptoms linked to a change in medication, a restricted eating pattern or a period of stress? A brief record of timing, food and symptoms can help an assessment if it remains manageable. We want an account that clarifies the difficulty, without asking someone to turn every meal into surveillance.

Support the eating pattern with fibre-containing foods such as vegetables, fruit, legumes and wholegrains, in amounts the person can tolerate. Changes can be gradual. Someone with a narrow food range may need help with preparation, texture or confidence before variety expands. Another person may need regular meals and easy access to fluids before a new food is useful. These are clinical choices that follow from the person's circumstances. Persistent symptoms need assessment so that the plan responds to what is causing trouble.

We also need to understand what happens when people become anxious about their gut. A succession of food rules can leave eating complicated and limited. A person may be trying hard to improve their health while losing confidence in ordinary meals. An OT can examine the daily routine and sensory demands; a dietitian or medical clinician can help investigate nutritional and digestive concerns. Support should make the relationship with food more workable as well as address symptoms.

Research on fermented foods, fibre and microbial activity gives us useful questions, but the everyday starting point remains nourishment and the experience of digestion. In SEEDS terms, the gut is connected with the wider pattern: stress, sleep, access to food, activity and the support around the person. We can take those connections seriously and choose a concrete place to begin. Understanding a painful or disrupted meal, making a tolerated food available, or getting a persistent symptom properly assessed may create room for the next part of care.

The evidence behind the article

Research notes and references

Facts: adult microbiome studies identify associations; the large GI cohort included ages 17–35 and did not measure microbes. Gut–brain pathways are mechanistically plausible, but gut-produced serotonin does not simply cross into the brain. The high-irritability PROBIA trial involved ADHD, borderline personality disorder or both: its primary responder result was 15/90 versus 4/90; attention was a secondary finding among multiple unadjusted tests. Other small studies have conflicting or null between-group outcomes. Interpretation: investigating digestion alongside attention is the author’s clinical formulation, not a claim that a single microbial abnormality causes ADHD. Patient application: address actual symptoms and nourish a tolerated, sustainable eating pattern. Findings are specific to preparations and populations and do not justify choosing a general probiotic as established ADHD treatment. Healthy-adult fermented-food work did not test ADHD.

References: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12.

  1. National Health and Medical Research Council. (2013). Australian Dietary Guidelines. Australian Government.

    Read source 1
    Study notes

    General nutrition guidance, not an ADHD treatment trial. Supports variety, water, limiting added sugars and saturated fats, and including unsaturated fats.

  2. Breda, V., Cerqueira, R. O., Ceolin, G., Koning, E., Fabe, J., McDonald, A., Gomes, F. A., & Brietzke, E. (2022). Is there a place for dietetic interventions in adult ADHD? Progress in Neuro-Psychopharmacology & Biological Psychiatry, 119, 110613. doi:10.1016/j.pnpbp.2022.110613.

    Read source 2
    Study notes

    Adult-focused narrative review. Dietary treatment evidence remains uncertain; few-foods findings chiefly concern children. Healthy eating can support broader wellbeing without being a proven ADHD cure.

  3. Jakobi, B., Vlaming, P., Mulder, D., et al. (2024). The gut-microbiome in adult Attention-deficit/hyperactivity disorder — A Meta-analysis. European Neuropsychopharmacology, 88, 21–29. doi:10.1016/j.euroneuro.2024.07.004.

    Read source 3
    Study notes

    Four adult case-control datasets: 312 ADHD participants and 305 controls. Associations do not establish microbiome causation or treatment benefit. This is the peer-reviewed version, rather than its 2023 preprint.

  4. Gomes, A., Siopa, C., Câmara Pestana, P., & Novais, F. (2025). The Effectiveness of the Gut Microbiota Modulation on ADHD in Adults: A Systematic Review. Current Treatment Options in Psychiatry, 12, article 20. doi:10.1007/s40501-025-00358-9.

    Read source 4
    Study notes

    Only three eligible adult trials, with heterogeneous products, participants and outcomes. Some promising findings, but insufficient consistent evidence for routine ADHD probiotic treatment. The positive basket trial selected high irritability.

  5. Sampson, T. R., & Mazmanian, S. K. (2015). Control of brain development, function, and behavior by the microbiome. Cell Host & Microbe, 17(5), 565–576. doi:10.1016/j.chom.2015.04.011.

    Read source 5
    Study notes

    Mechanistic review, substantially animal and preclinical evidence. Gut-brain communication involves several pathways. Gut-made serotonin does not directly cross into the brain; this does not establish an adult ADHD treatment.

  6. Adamou, M., et al. (2021). Recommendations for occupational therapy interventions for adults with ADHD: a consensus statement from the UK adult ADHD network. BMC Psychiatry, 21, 72. doi 10.1186/s12888-021-03070-z.

    Read source 6
    Study notes

    Expert consensus about OT assessment and intervention. A practice framework, not a trial showing that all proposed strategies improve ADHD symptoms.

  7. Yano, J. M., Yu, K., Donaldson, G. P., Shastri, G. G., Ann, P., Ma, L., Nagler, C. R., Ismagilov, R. F., Mazmanian, S. K., & Hsiao, E. Y. (2015). Indigenous Bacteria from the Gut Microbiota Regulate Host Serotonin Biosynthesis. Cell, 161(2), 264–276. doi:10.1016/j.cell.2015.02.047.

    Read source 7
    Study notes

    Mice and cultured cells; human microbial material was transferred into mice. Not a human ADHD trial. Selected microbial communities and metabolites increased serotonin synthesis in host colonic enterochromaffin cells, affecting peripheral serotonin, gut motility and platelet function. Primary evidence for microbial effects on gut serotonin, not an adult ADHD treatment. Most gut serotonin is produced by host gut cells. This paper must not become a claim that most neurotransmitters/cells are in the gut or that gut serotonin directly supplies brain serotonin.

  8. Wastyk, H. C., Fragiadakis, G. K., Perelman, D., et al. (2021). Gut-microbiota-targeted diets modulate human immune status. Cell, 184(16), 4137–4153.e14. doi:10.1016/j.cell.2021.06.019.

    Read source 8
    Study notes

    36 generally healthy adults, 18 per diet arm. No ADHD sample. The fermented-food diet increased microbiota diversity and reduced some inflammatory markers. Fibre changed microbial carbohydrate-processing capacity without increasing diversity. The prespecified cytokine-response-score outcome was unchanged. Small, open-label study without a usual-diet control. Biological changes do not establish better attention, clinical ADHD improvement, or a universal ideal microbiome. Fermented foods are a food option, not an ADHD prescription.

  9. Levy Schwartz, M., Magzal, F., Yehuda, I., & Tamir, S. (2024). Exploring the impact of probiotics on adult ADHD management through a double-blind RCT. Scientific Reports, 14, 26830. doi:10.1038/s41598-024-73874-y.

    Read source 9
    Study notes

    Israeli college students with ADHD, eligibility age 19–30 and mean age about 27; not taking ADHD medication; mostly women. Authors reported within-probiotic-arm improvements in computerized hyperactivity and GI symptoms. Attention, timing and impulsivity did not improve in that arm; placebo participants improved on impulsivity. Academic improvement was not statistically significant between groups. Key positive tests compared each arm with its own baseline, which cannot establish treatment superiority. Small completer sample, multiple outcomes/subgroups, narrow population and no microbiome measurement. Do not advertise this as proof that probiotics treat adult ADHD or improve academic achievement.

  10. Arteaga-Henríquez, G., Ramos-Sayalero, C., Ibañez-Jimenez, P., et al. (2024). Efficacy of a synbiotic in the management of adults with Attention-Deficit and Hyperactivity Disorder and/or Borderline Personality Disorder and high levels of irritability: Results from a multicenter, randomized, placebo-controlled, ‘basket’ trial. Brain, Behavior, and Immunity, 120, 360–371. doi:10.1016/j.bbi.2024.06.012.

    Read source 10
    Study notes

    Ten-week double-blind randomized trial of 180 adults: 113 ADHD, 44 BPD, 23 both, all selected for high irritability. Responder rates were 15/90 versus 4/90; response combined ≥30% irritability reduction with clinician-rated improvement. Secondary adjusted between-group inattention difference was -1.8 (95% CI -3.2 to -0.4; p=.01); emotional regulation and functioning also favoured synbiotic. Mixed diagnoses, attrition and unadjusted multiple secondary tests limit generalisation. Does not test ordinary food or establish the biological mechanism. Primary abstract plus indexed full-text methods/results/limitations checked against the institutional record.

  11. Yang, L. L., Stiernborg, M., Skott, E., et al. (2023). Effects of a Synbiotic on Plasma Immune Activity Markers and Short-Chain Fatty Acids in Children and Adults with ADHD—A Randomized Controlled Trial. Nutrients, 15(5), 1293. doi:10.3390/nu15051293.

    Read source 11
    Study notes

    Biomarker analysis nested within a nine-week trial of 248 children/adults; 156 provided paired blood samples. Adult ADHD participants had higher baseline vascular inflammatory markers sICAM-1/sVCAM-1 and differences in short-chain fatty acids versus controls. Adult intervention effects were mainly exploratory subgroup signals; no uniform adult biomarker correction. Supports examining gut-related metabolites and immune signalling in ADHD biology, without converting a biomarker finding into proven symptom treatment. Primary PDF methods/results/discussion read; adult and child outcomes kept separate.

  12. Kedem, S., Yust-Katz, S., Carter, D., Levi, Z., Kedem, R., Dickstein, A., Daher, S., & Katz, L. H. (2020). Attention deficit hyperactivity disorder and gastrointestinal morbidity in a large cohort of young adults. World Journal of Gastroenterology, 26(42), 6626–6637. doi:10.3748/wjg.v26.i42.6626.

    Read source 12
    Study notes

    Primary publisher full text inspected, including cohort definitions and limitations. Retrospective Israeli military cohort aged 17–35: 33,380 with ADHD and 355,652 controls, service records 2007–2016. ADHD was associated with constipation, dyspepsia and IBS (adjusted odds ratios 1.64, 1.48, 1.67), not IBD/celiac disease. It includes 17-year-olds and a selected military population; broad ADHD definitions, coding and healthcare-use differences limit interpretation. Microbiota, causality and benefits of integrated treatment were not tested.